B. longum is composed to date of four subspecies, B. longum ssp. infantis relieved many of the symptoms of IBS in a clinical trial involving women [32]. thermophilus, see Table 1 for details) by children with newly diagnosed UC in conjunction with IBD therapy demonstrated significant efficacy for inducing and maintaining remission (p<0.001) compared with placebo and IBD therapy.88 A significantly lower rate of relapse was recorded in the VSL#3 group (p=0.014). In most cases, the strains were administered orally. Significantly reduced duration of sore throat; Seasonal allergic rhinitis & intermittent asthma, Significantly relieved nasal symptoms of allergic rhinitis & improved quality of life. Formulations containing B. longum have also generated promising results in improving symptoms of irritable bowel syndrome (IBS) and ulcerative colitis (UC) in children. A follow-on study revealed that the bacterial formulation was associated with increased Bifidobacterium in the gut microbiota of the very preterm infants (p<0.001) and decreased Enterococcus levels (p = 0.02), suggesting that Bifidobacterium may have a protective effect against NEC.73 The bacterial formulations of B. longum, L. acidophilus, Lactobacillus rhamnosus (now Lacticaseibacillus rhamnosus), and Saccharomyces boulardii showed a trend toward lowering NEC (4% versus 12%) in very low birth weight neonates in a randomized, double-blinded controlled trial where breast milk served as the control (no placebo included).74 However, the authors suggest that the use of breast milk in the control group may have narrowed the differences between the two groups given the beneficial properties associated with breast milk. Many bifidobacteria produce polysaccharides including capsular polysaccharides (CPSs) that are bound to the cell surface and exopolysaccharides (EPSs) that are loosely attached to the bacterial cell or secreted into the surrounding environment.52 These molecules serve to protect bacterial cells against harsh environments encountered in the gastrointestinal tract but can also be involved in crosstalk with the gut environment. Bifidobacterium Longum: Bifidobacterium Longum increases the generation of acetate, regulates the immune system, and reduces inflammation. Notably, the name B. longum ssp. B. longum attenuated allergic airway inflammation [46] and food allergy symptoms in mice [47]. gut. Total number of trials conducted in each category is provided, as well as number of trials conducted in infants and children, adults, and the elderly. infantis is often shortened to B. infantis in the literature and B. longum ssp. The administration of these strains on elderly nursing home residents suffering from constipation should help improve quality of life. A meta-analysis conducted by Patel et al.190 reported that the placebo response in participants with IBS can range from 16% to 71% for pharmaceutical interventions or natural health products. lactis BB-12 (in maltodextrin powder) and the placebo group received maltodextrin. Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. * Notre mlange unique est conu pour aider promouvoir la sant digestive et peut aider apaiser les problmes digestifs courants, comme les maux d'estomac, les gaz . Pyclik M, Srutkova D, Schwarzer M, Grska S. Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins their chemical structure and biological attributes. SelfDecode does not treat, diagnose or cure any conditions, The formulation consisted of three different Bifidobacterium species, namely B. longum ssp. Our goal is to not have a single piece of inaccurate information on this website. However, the studies listed below should not be interpreted as supportive of any health benefit. In this review, we refer to the names provided in the literature. B. longum reduced total cholesterol, particularly among subjects with moderate hypercholesterolemia [51]. Subsequent clinical course was uneventful. The microbiota-gut-brain axis describes the bi-directional communication pathways between the gut microbiota and its metabolites, the central, enteric, and autonomic nervous systems, and the hypothalamic-pituitary-adrenal axis.118 Certain members of the gut microbiota, including B. longum, have been shown to produce neurochemicals such as the major inhibitory neurotransmitter gamma amino butyric acid,119 or are involved in the regulation of host serotonin biosynthesis.120,121 Furthermore, bacterially produced SCFAs are involved in the microbiota-gut-brain axis with the potential to influence mood, cognition, and brain disorder etiology, directly or indirectly.122. Bifidobacterium longum is a very important microbe in the digestive system. infantis triggered the anti-poliovirus response in a small study of 20 infants [2]. While its relative abundance declines with age, it is further reduced in several diseases. In a randomized, double-blind, placebo-controlled pilot study of 44 adults with IBS and diarrhea or a diarrhea/constipation-stool pattern and mild to moderate anxiety and/or depression, B. longum NCC3001 showed benefit for reducing depression (but not anxiety scores) and increasing quality of life in patients with IBS.From the study, "These improvements were associated with changes in brain activation patterns that indicate that this probiotic reduces limbic reactivity." The bacterial strains had no impact on the risk of atopic sensitization in infants. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice, The gut-brain axis, BDNF, NMDA and CNS disorders. Upper respiratory tract infections describe viral or bacterial infections of the nose, pharynx, larynx, sinuses, and large airways, and have been identified as one of the top three diagnoses in outpatient settings.128 In 2003, it was estimated that non-influenza-related, viral respiratory tract infections in the United States posed an annual economic burden above $22 billion.129 Seasonal allergies, including hay fever or allergic rhinitis, occur at a certain time of the year when pollen counts are high with symptoms of runny nose, watery eyes, coughing, and sneezing. Despite the promising results, the authors suggest that clinician-administered rating scales may be superior to the HAD scale used in this study. In a mouse model, acetate produced in the gut by bifidobacteria has been shown to improve intestinal defenses and protect against infection.39 Acetate and lactate reduce the pH in the gut, which is believed to prevent microbiota imbalances and prevent pathogen growth.40,41 Indeed, Henrick et al.42 reported a trend for increasing fecal pH in breast-fed infants over the past century (from 5.0 to 6.5) that is associated with loss of specialized Bifidobacterium species and may pose increased risk for microbiota dysbiosis. 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B. longum extract, when applied to the skin, was able to improve inflammation parameters, decrease skin sensitivity, increase skin resistance against physical and chemical aggression, and decrease skin dryness in volunteers with sensitive skin [55]. The washout period of 5weeks was deemed too short since a carryover effect was observed for the cytokines in participants who had initially received the formulation but were then in the placebo group in period 2. for Cohort Studies of Memory in an International Consortium, Cosmic) RS, Pabst A, Riedel-Heller SG, Jessen F, Turana Y, Handajani YS, Brayne C, Matthews FE, Stephan BCM, et al. It has NO additives and none of the common allergens listed below. Bifidobacterium longum agit pour rduire la graisse naturelle de votre corps connue pour vincer les mauvaises bactries intestinales, contribuant ainsi une prise de poids indsirable. In a study involving 362 primary care IBS patients, B. infantis 35624 failed to provide relief from symptoms at doses of 106 and 1010 colony forming units (CFU)/ml for 4weeks but at 108 CFU/ml the strain significantly relieved many IBS symptoms compared with placebo (and other doses) including abdominal pain, as well as bloating, bowel dysfunction, flatulence, straining, and incomplete evacuation. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. breve M-16V proved effective for significantly relieving nasal symptoms of allergic rhinitis (nasal itching, nasal obstruction, sneezing, rhinorrhea, and itchy eyes; p<0.005) and improving quality of life (p<0.001) in children suffering from seasonal allergic rhinitis and intermittent asthma due to pollen.95 However, the small sample size used in this trial (n=40) suggests that further trials with larger participant numbers are needed to confirm the findings. regular medical care. Bifidobacterium Infantis: Bifidobacterium Infantis can . Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. An overview of clinical trials investigating the impact of B. longum on adults. Kordy K, Gaufin T, Mwangi M, Li F, Cerini C, Lee DJ, Adisetiyo H, Woodward C, Pannaraj PS, Tobin NH, et al. Ki Cha et al.159 investigated the impact of a seven-strain species mix on diarrhea-dominant IBS that consisted of B. longum, L. acidophilus, L. plantarum, L. rhamnosus, B. breve, B. lactis, and S. thermophilus following daily treatment for 8weeks. Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions Ive ever made in my life! Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, Panzer AR, LaMere B, Rackaityte E, Lukacs NW, et al. 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